Descriptif

Ce cours présente les principales stratégies permettant de modifier les surfaces des grandes familles de (bio)matériaux par le biais de la fonctionnalisation moléculaire et met en évidence la manière dont ces concepts peuvent être étendus des surfaces 2D aux architectures 3D complexes grâce à la bio-impression. Une attention particulière sera accordée au rôle des propriétés de surface dans l'utilisation et la conception des bio-encres et des structures bio-imprimées, établissant ainsi un lien direct entre la bio-ingénierie des surfaces, les interactions cellule-matériau et la bio-impression 3D.

The course is divided into three blocks:   

• the description of the main families of (bio)materials and nanomaterials including their synthesis and their characteristics in terms of physical, mechanical and chemical properties.
• the preparation and activation procedures of the materials together with their chemical functionalization using plasma polymerization, physical deposit or (electro)chemical grafting. Strategies to design antimicrobial coatings will be also discussed.
• the biodetection of analytes including O₂, signaling molecules, metabolites, biomarkers, and pathogens using optical (fluorescence, surface plasmon resonance, surface-enhanced Raman scattering), magnetic, piezoelectric or electrochemistry approaches.

In parallel, several lab sessions will be dedicated to the syntheses and characterization of noble metal particles for the optical detection of analytes.

Prequesite

Basic knowledge in chemistry of materials

Evaluation

Students are evaluated on the basis of a written exam (2/3) and a final oral presentation (1/3)